Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.98.1.1 extracted from

  • Miyake, M.; Ishii, M.; Kawashima, K.; Kodama, T.; Sugano, K.; Fujimoto, K.; Hirao, Y.
    siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines (2009), Photochem. Photobiol., 85, 1020-1027.
    View publication on PubMed

Application

Application Comment Organism
medicine siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA transfection downregulates the endogenous gene expression of ferrochelatase in urothelial cancer cell lines Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrin IX + Fe2+ Homo sapiens
-
protoheme IX + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22830
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrin IX + Fe2+
-
Homo sapiens protoheme IX + 2 H+
-
?

Synonyms

Synonyms Comment Organism
FeCH
-
Homo sapiens
ferrochelatase
-
Homo sapiens

General Information

General Information Comment Organism
additional information siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines Homo sapiens