Application | Comment | Organism |
---|---|---|
medicine | siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA transfection downregulates the endogenous gene expression of ferrochelatase in urothelial cancer cell lines | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrin IX + Fe2+ | Homo sapiens | - |
protoheme IX + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22830 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrin IX + Fe2+ | - |
Homo sapiens | protoheme IX + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FeCH | - |
Homo sapiens |
ferrochelatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | siRNA-mediated knockdown of ferrochelatase suppresses heme synthesis and significantly increases intracellular protoporphyrin IX (PpIX) accumulation, this improves the phototoxicity of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines | Homo sapiens |