Literature summary for 4.98.1.1 extracted from

Amo, T.; Kawanishi, N.; Uchida, M.; Fujita, H.; Oyanagi, E.; Utsumi, T.; Ogino, T.; Inoue, K.; Shuin, T.; Utsumi, K.; Sasaki, J.
Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937 (2009), Cell Biochem. Funct., 27, 503-515.

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Application

Application	Comment	Organism
medicine	photodynamic therapy (PDT) for tumors is based on the tumor-selective accumulation of a photosensitizer, protoporphyrin IX (PpIX), followed by irradiation with visible light, PpIX accumulation in 5-aminolevulinic acid, treated U937 cells is increased by the inhibition of ferrochelatase	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
deferoxamine	-	Homo sapiens
Mn2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protoporphyrin IX + Fe2+	Homo sapiens	-	protoheme IX + 2 H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protoporphyrin IX + Fe2+	-	Homo sapiens	protoheme IX + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
ferrochelatase	-	Homo sapiens

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Release 2023.1 (January 2023)