Literature summary for 4.98.1.1 extracted from

Franco, R.; Ma, J.G.; Lu, Y.; Ferreira, G.C.; Shelnutt, J.A.
Porphyrin interactions with wild-type and mutant mouse ferrochelatase (2000), Biochemistry, 39, 2517-2529.

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Protein Variants

Protein Variants	Comment	Organism
E287Q	addition of metalated porphyrins is substoichiometric	Mus musculus
H207N	addition of metalated porphyrins yields a 1:1 complex comparable with wild type	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
protoheme + 2 H+ = protoporphyrin + Fe2+	mechanism	Mus musculus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	in wild type and H207N mutant, addition of porphyrin yields a 1:1 complex with protein, in E287Q mutant addition is in in substoichiometric ratio with protein	Mus musculus	?	-	?

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Release 2023.1 (January 2023)