Literature summary for 4.98.1.1 extracted from

Gora, M.; Rytka, J.; Labbe-Bois, R.
Activity and cellular location in Saccharomyces cerevisiae of chimeric mouse/yeast and Bacillus subtilis/yeast ferrochelatases (1999), Arch. Biochem. Biophys., 361, 231-240.

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Protein Variants

Protein Variants	Comment	Organism
additional information	exchange of about 40 amino acid C-terminus with Mus musculus enzyme leads to total loss of activity and unstable chimeric proteins, fusion protein of Saccharomyces cerevisiae N-terminal leader sequence with Bacillus subtilis enzyme targets fusion product to mitochondria but it remains inactive, identification of a N-terminal segment responsible for association of enzyme with the membrane	Saccharomyces cerevisiae
additional information	exchange of about 40 amino acid C-terminus with Sacharomyces cerevisiae enzyme leads to total loss of activity and unstable chimeric proteins	Mus musculus
additional information	fusion protein of Saccharomyces cerevisiae N-terminal leader sequence with Bacillus subtilis enzyme targets fusion product to mitochondria but it remains inactive, identification of a N-terminal segment responsible for association of enzyme with the membrane	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	recombinant enzyme, expression in Saccharomyces cerevisiae	-
Mus musculus	-	recombinant enzyme expressed in Escherichia coli	-
Saccharomyces cerevisiae	-	recombinant enzyme	-

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Release 2023.1 (January 2023)