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Literature summary for 4.98.1.1 extracted from

  • Dailey, H.A.; Sellers, V.M.; Dailey, T.A.
    Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases (1994), J. Biol. Chem., 269, 390-395.
    View publication on PubMed
Search for more literature for 4.98.1.1

Protein Variants

Protein Variants Comment Organism
F417S less than 2% of normal activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 Fe2+
-
 Homo sapiens
0.0111
-
 Fe2+
-
 Mus musculus
0.0153
-
 protoporphyrin
-
 Mus musculus
0.0168
-
 protoporphyrin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrin IX + Fe2+ Mus musculus final step of heme biosynthesis ?
-
 ?
protoporphyrin IX + Fe2+ Homo sapiens final step of heme biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
expressed in Escherichia coli Mus musculus
expressed in Escherichia coli Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrin + Fe2+
-
 Mus musculus protoheme + 2 H+
-
 ?
protoporphyrin + Fe2+
-
 Homo sapiens protoheme + 2 H+
-
 ?
protoporphyrin IX + Fe2+ final step of heme biosynthesis Mus musculus ?
-
 ?
protoporphyrin IX + Fe2+ final step of heme biosynthesis Homo sapiens ?
-
 ?