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Literature summary for 4.6.1.22 extracted from
- ATP-inhibited ribonuclease of Bacillus subtilis. II. Effect of adenosine triphosphate and other compounds (1970), Biochim. Biophys. Acta, 209, 475-483.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | inhibition influenced by pH, enhanced inhibition at pH 7.5; less effective than ATP but more potent in the crude ribonuclease preparation | Bacillus subtilis |  |
| ATP | inhibition influenced by pH, enhanced inhibition at pH 7.5 | Bacillus subtilis | |
| calf thymus native DNA | slight | Bacillus subtilis | |
| dATP | inhibition influenced by pH, enhanced inhibition at pH 7.5 | Bacillus subtilis | |
| diazo-1H-tetrazol | - |
Bacillus subtilis | |
| GDP | less effective than ATP, competitive inhibitor, inhibition influenced by pH, enhanced inhibition at pH 7.0 | Bacillus subtilis | |
| GTP | less effective than ATP, competitive inhibitor, inhibition influenced by pH, enhanced inhibition at pH 7.0 | Bacillus subtilis | |
| UDP | slight at pH 7.0 | Bacillus subtilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | slight | Bacillus subtilis | |
| Co2+ | slight | Bacillus subtilis | |
| Cu2+ | - |
Bacillus subtilis | |
| Hg2+ | - |
Bacillus subtilis | |
| Ni2+ | slight | Bacillus subtilis | |
| Zn2+ | slight | Bacillus subtilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
gel filtration | Bacillus subtilis |
| 25000 | - |
allosteric mechanism | Bacillus subtilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA + H2O | Bacillus subtilis | - |
2',3'-cyclic nucleotides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA + H2O | - |
Bacillus subtilis | 2',3'-cyclic nucleotides | - |
? | |
| RNA + H2O | e.g. yeast RNA | Bacillus subtilis | 2',3'-cyclic nucleotides | - |
? | |
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