Literature summary for 4.6.1.2 extracted from

Peshenko, I.V.; Olshevskaya, E.V.; Dizhoor, A.M.
Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs) (2015), J. Biol. Chem., 290, 6913-6924 .

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
GCAP1	activating protein. At near-saturating concentrations, GCAP1 and GCAP2 activate RetGC1 from HEK293 in a non-additive fashion. GCAP1 mutant M26R binds but does not activate RetGC1 and suppresses activation of recombinant and native RetGC1 by competing with both GCAP1 and GCAP2	Homo sapiens
GCAP2	activating protein. At near-saturating concentrations, GCAP1 and GCAP2 activate RetGC1 from HEK293 in a non-additive fashion. Deletion of a residues Tyr1016-Ser1103 fragment in RetGC1 does not block GCAP2 binding to the cyclase. Substitutions in the kinase homology domain, W708R and I734T, linked to Leber congenital amaurosis prevent binding of both GCAP1-GFP and GCAP2-GFP	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
I734T	substitution in the kinase homology domain linked to Leber congenital amaurosis, prevents binding of both GCAP1-GFP and GCAP2-GFP	Homo sapiens
additional information	deletion of a residues Tyr1016-Ser1103 fragment in RetGC1 does not block GCAP2 binding to the cyclase	Homo sapiens
W708R	substitution in the kinase homology domain linked to Leber congenital amaurosis, prevents binding of both GCAP1-GFP and GCAP2-GFP	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02846	isoform RetGC1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	-	Homo sapiens	-

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Release 2023.1 (January 2023)