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Literature summary for 4.6.1.2 extracted from

  • Miller, T.W.; Isenberg, J.S.; Roberts, D.D.
    Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase (2010), Br. J. Pharmacol., 159, 1542-1547.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-2272 heme-dependent sGC activator Homo sapiens
meso-porphyrin IX heme-independent activator Homo sapiens
nitric oxide stimulates activity if sGC, 2.2 nM thrombospondin-1 binds to CD47 and potently inhibits nitric oxide stimulation of sGC Homo sapiens
YC-1 heme-dependent sGC activator Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
thrombospondin-1 thrombospondin-1 is a universal inhibitor of sGC, blocking both hemedependent and heme-independent activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic-GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-
blood vessel endothelium
-
 Homo sapiens
-
vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens