Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BAY 41-2272 | - |
Homo sapiens | |
nitric oxide | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | NS-2028, a soluble guanylyl cyclase inhibitor, complete inhibition at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic-GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic-GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of soluble guanylyl cyclase reduces vascular endothelial growth factor-induced angiogenesis and permeability | Homo sapiens |
physiological function | soluble guanylyl cyclase mediates the angiogenic and permeability-promoting activities of vascular endothelial growth factor. Soluble guanylyl cyclase is a downstream effector of vascular endothelial growth factor-triggered responses | Homo sapiens |