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Literature summary for 4.6.1.2 extracted from

  • Vanneste, G.; Van Nassauw, L.; Kalfin, R.; Van Colen, I.; Elinck, E.; Van Crombruggen, K.; Timmermans, J.P.; Lefebvre, R.A.
    Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus (2008), Surgery, 144, 410-426.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NO
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo [4,3,-a]quinoxalin-1-one i.e. ODQ, in vivo treatment with the sGC inhibitors ODQ does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical field-induced relaxation; i.e. ODQ, in vivo treatment with the sGC inhibitors ODQ does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical field-induced relaxation Rattus norvegicus
methylene blue in vivo treatment with the sGC inhibitor methylene blue does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical filed stimulation-induced relaxation; in vivo treatment with the sGC inhibitor methylene blue does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical filed stimulation-induced relaxation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus role of soluble guanylate cyclase during the inflammatory phase of postoperative illius, overview 3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q02108 male Wistar-Han rats
-
Rattus norvegicus Q02153 beta-subunit; male Wistar-Han rats
-

Source Tissue

Source Tissue Comment Organism Textmining
ileum
-
Rattus norvegicus
-
intestine
-
Rattus norvegicus
-
jejunum
-
Rattus norvegicus
-
smooth muscle gastrointestinal Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
?
GTP role of soluble guanylate cyclase during the inflammatory phase of postoperative illius, overview Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sGC
-
Rattus norvegicus
soluble guanylate cyclase
-
Rattus norvegicus