Literature summary for 4.6.1.2 extracted from

Lauber, T.; Tidten, N.; Matecko, I.; Zeeb, M.; Roesch, P.; Marx, U.C.
Design and characterization of a soluble fragment of the extracellular ligand-binding domain of the peptide hormone receptor guanylyl cyclase-C (2009), Protein Eng. Des. Sel., 22, 1-7.

Search for more literature for 4.6.1.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression of a Trx-tagged miniGC-C, comprising the extracellular domain, in Escherichia coli strain AD494(DE3) using expression vector pET-32a	Sus scrofa

Protein Variants

Protein Variants	Comment	Organism
additional information	recombinant miniGC-C, comprising the exracellular enzyme domain, binds the heat-stable enterotoxin STp-(5-17) with high affinity, ligand binding and structure analysis, overview	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	GC-C	Sus scrofa	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Sus scrofa	guanylyl cyclase-C is a peptide hormone receptor	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P55204	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant Trx-tagged miniGC-C, comprising the extracellular domain, from Escherichia coli strain AD494(DE3) by Co2+ affinity chromatography, dialysis and ultrafiltration, cleavage of the thioredoxin tag	Sus scrofa

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	GC-C	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	guanylyl cyclase-C is a peptide hormone receptor	Sus scrofa	3',5'-cyclic GMP + diphosphate	-	?
GTP	guanylin-GC-C interaction, overview	Sus scrofa	3',5'-cyclic GMP + diphosphate	-	?

Subunits

Subunits	Comment	Organism
More	homology structure modeling of the extracellular domain of GC-C, GC-C structure analysis by NMR and fluorescence emission spectroscopy, overview	Sus scrofa

Synonyms

Synonyms	Comment	Organism
GC-C	-	Sus scrofa
guanylyl cyclase-C	-	Sus scrofa
peptide hormone receptor guanylyl cyclase-C	-	Sus scrofa
STA	-	Sus scrofa

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Release 2023.1 (January 2023)