Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NO | nitric oxide-sensitive guanylate cyclase | Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Cavia porcellus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Cavia porcellus | NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
adult female Hartley guinea pigs | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | smooth muscle | Cavia porcellus | - |
colon | smooth muscle, low enzyme expression | Cavia porcellus | - |
gastrointestinal tract | smooth muscle and myenteric layer | Cavia porcellus | - |
large intestine | - |
Cavia porcellus | - |
additional information | analysis of sGC in gastrointestinal tissue, immunohistochemic analysis | Cavia porcellus | - |
neuron | - |
Cavia porcellus | - |
smooth muscle | gastrointestinal tract, muscularis mucosae and vasculature | Cavia porcellus | - |
stomach | smooth muscle, low enzyme expression | Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Cavia porcellus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration | Cavia porcellus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nitric oxide-sensitive guanylate cyclase | - |
Cavia porcellus |
NO-sensitive GC | - |
Cavia porcellus |
sGC | - |
Cavia porcellus |
soluble guanylate cyclase | - |
Cavia porcellus |