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Literature summary for 4.6.1.2 extracted from

  • De Backer, O.; Elinck, E.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
    Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus (2008), Naunyn Schmiedebergs Arch. Pharmacol., 378, 493-502.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
CO
-
 Mus musculus
CORM-2 i.e. CO-releasing molecule-2, a tricarbonyldichlororuthenium(II) dimer Mus musculus
YC-1 i.e. 1-benzyl-3-(5'-hydroxymethyl-2'-furyl-)-indazol, a sGC sensitizer, able to potentiate CO- and CORM-2-induced relaxations in wild-type mice Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction and phenotype of sGCalpha1 KO mice, expression levels of sGC subunits are altered in the mutant compared to the wild-type mice, the KO mice show reduced enzyme activation and induced muscle relaxation by CO, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one i.e. ODQ, a sGC inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Mus musculus soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
additional information soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Mus musculus
soluble guanylyl cyclase
-
 Mus musculus