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Literature summary for 4.6.1.2 extracted from

  • Gambaryan, S.; Kobsar, A.; Hartmann, S.; Birschmann, I.; Kuhlencordt, P.J.; Mueller-Esterl, W.; Lohmann, S.M.; Walter, U.
    NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity (2008), J. Thromb. Haemost., 6, 1376-1384.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
von Willebrand factor/ristocetin increase the enzyme activity in an NO-independent manner correlating with Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 Mus musculus
von Willebrand factor/ristocetin increases the enzyme activity in an NO-independent manner correlating with Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Homo sapiens von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activation by Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 Mus musculus
phosphoprotein activation by Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?