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Literature summary for 4.6.1.2 extracted from

  • Snook, A.E.; Stafford, B.J.; Li, P.; Tan, G.; Huang, L.; Birbe, R.; Schulz, S.; Schnell, M.J.; Thakur, M.; Rothstein, J.L.; Eisenlohr, L.C.; Waldman, S.A.
    Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity (2008), J. Natl. Cancer Inst., 100, 950-961.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of the His6-tagged truncated enzyme mutant in CT26 mouse colon cancer cells, subclining in 293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of a truncated GCC 1-430 construct, GCC ECD, containing the extracellular ligand-binding domain and a C-terminus His6-tag in in colorectal cancer cells using a viral vector, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Mus musculus BALB/c
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3UWA6 GCC; Balb/c mice
-
Mus musculus BALB/c Q3UWA6 GCC; Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells. Isozyme GCC is universally expressed by primary and metastatic colorectal tumors Mus musculus
-
intestine guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells Mus musculus
-
MC-38 cell C57BL/6-derived colorectal cancer cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP
-
 Mus musculus BALB/c 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GCC
-
 Mus musculus
guanylyl cyclase C
-
 Mus musculus
More GC-C is a member of the particulate guanylyl cyclase family Mus musculus