Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cinaciguat | i.e. 4-([(4-carboxybutyl)[2-(2-[[4-(2-phenylethyl)benzyl]oxy]phenyl)ethyl]amino]methyl) benzoic acid or BAY 58-2667, analysis of safety, tolerability, pharmacokinetics, and pharmacodynamics of cinaciguat in treatment of patients with heart failure, the agent induces vasodilation preferentially in diseased vessels, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | the soluble guanylate cyclase is a target for compounds used in therapy of heart failure, e.g. nitric oxide-independent, soluble guanylate cyclase activator cinaciguat, BAY 58-2667, that induces vasodilation preferentially in diseased vessels, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
male | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylate cyclase | - |
Homo sapiens |