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Literature summary for 4.6.1.2 extracted from

  • Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
    Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers (2008), J. Clin. Pharmacol., 48, 1400-1410.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cinaciguat i.e. 4-([(4-carboxybutyl)[2-(2-[[4-(2-phenylethyl)benzyl]oxy]phenyl)ethyl]amino]methyl) benzoic acid or BAY 58-2667, analysis of safety, tolerability, pharmacokinetics, and pharmacodynamics of cinaciguat in treatment of patients with heart failure, the agent induces vasodilation preferentially in diseased vessels, overview Homo sapiens

Application

Application Comment Organism
drug development the soluble guanylate cyclase is a target for compounds used in therapy of heart failure, e.g. nitric oxide-independent, soluble guanylate cyclase activator cinaciguat, BAY 58-2667, that induces vasodilation preferentially in diseased vessels, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
male
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sGC
-
Homo sapiens
soluble guanylate cyclase
-
Homo sapiens