Activating Compound | Comment | Organism | Structure |
---|---|---|---|
neuronal calcium sensor GCAP1 | confers Ca2+ sensitivity to guanylyl cyclase activity | Mus musculus | |
neuronal calcium sensor GCAP2 | confers Ca2+ sensitivity to guanylyl cyclase activity, absence of GCAP2 affected guanylyl cyclase activity in two ways: 1. the maximal rate of cGMP synthesis at low [Ca2] dropps 2fold and 2. the half-maximal rate of cGMP synthesis is attained at a higher than normal [Ca2+], phenotype of GCAP2 knockout mice, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the two neuronal calcium sensors, GCAP1 and GCAP2, confer Ca2+ sensitivity to guanylyl cyclase activity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors | 3',5'-cyclic GMP + diphosphate | cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme retGC | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors | Mus musculus | 3',5'-cyclic GMP + diphosphate | cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels | ? |
Synonyms | Comment | Organism |
---|---|---|
retGC | - |
Mus musculus |
retinal membrane guanylyl cyclase | - |
Mus musculus |