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Literature summary for 4.6.1.2 extracted from

  • Lin, H.; Cheng, C.F.; Hou, H.H.; Lian, W.S.; Chao, Y.C.; Ciou, Y.Y.; Djoko, B.; Tsai, M.T.; Cheng, C.J.; Yang, R.B.
    Disruption of guanylyl cyclase-G protects against acute renal injury (2008), J. Am. Soc. Nephrol., 19, 339-348.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of a mutant mouse with a targeted disruption of the GC-G gene Gucy2g, which shows no histologic abnormalities at baseline, but after I/R injury, elevations in serum creatinine and urea are attenuated in GC-G knockout mice compared with wild-type controls, and this correlated with less tubular disruption, less tubular cell apoptosis, and less caspase-3 activation, phenotype, overview. Direct transfer of a GC-G expression plasmid to the kidneys of GC-G-deficient mice results in a dramatically higher mortality after renal I/R injury Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus membrane forms of guanylyl cyclase serve as cell-surface receptors that synthesize the second messenger cGMP, which mediates diverse cellular processes. GC-G plays a role in mediating injury, GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury 3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6TL19 gene Gucy2g encoding isozyme GC-G
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
Mus musculus
-
kidney epithelial cells of the proximal tubule and collecting ducts Mus musculus
-
testis
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Mus musculus 3',5'-cyclic GMP + diphosphate
-
?
GTP membrane forms of guanylyl cyclase serve as cell-surface receptors that synthesize the second messenger cGMP, which mediates diverse cellular processes. GC-G plays a role in mediating injury, GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury Mus musculus 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
GC-G
-
Mus musculus
guanylyl cyclase-G
-
Mus musculus