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Literature summary for 4.6.1.2 extracted from
- Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork (2008), Invest. Ophthalmol. Vis. Sci., 50, 1808-1813.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| diethylenetriamine nitric oxide | - |
Sus scrofa |  |
| NO | activates the soluble guanylate cyclase, the activation is abolished by 1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one | Homo sapiens | |
| NO | activates the soluble guanylate cyclase, the activation is abolished by 1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | complete inhibition at 0.001 mM | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Homo sapiens | - |
- |
| soluble | - |
Sus scrofa | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Sus scrofa | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Sus scrofa | - |
3',5'-cyclic-GMP + diphosphate | - |
? | |
| additional information | Homo sapiens | sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye | ? | - |
? | |
| additional information | Sus scrofa | sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | - |
Sus scrofa | - |
| eye | anterior segment | Homo sapiens | - |
| eye | anterior segment | Sus scrofa | - |
| reticulum trabeculare | - |
Sus scrofa | - |
| trabecular meshwork | - |
Homo sapiens | - |
| trabecular meshwork | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Sus scrofa | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Sus scrofa | 3',5'-cyclic-GMP + diphosphate | - |
? | |
| additional information | sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye | Homo sapiens | ? | - |
? | |
| additional information | sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye | Sus scrofa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | the enzyme is active as a heterodimer of alpha and beta subunits, but probably requires additional components for activity | Homo sapiens |
| dimer | the enzyme is active as a heterodimer of alpha and beta subunits, but probably requires additional components for activity | Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sGC | - |
Homo sapiens |
| sGC | - |
Sus scrofa |
| soluble guanylate cyclase | - |
Homo sapiens |
| soluble guanylate cyclase | - |
Sus scrofa |
| soluble guanylyl cyclase | - |
Sus scrofa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | activation of sGC is involved in the nitric oxide-induced increases in outflow facility of the eye | Sus scrofa |
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