Protein Variants | Comment | Organism |
---|---|---|
additional information | mice deficient in isozyme GC-A show marked cardiac hypertrophy and fibrosis, which can be inhibited by both genetic and pharmacological blockade of type 1 angiotensin II receptors. The mutant mice show increased expression of atrial and brain natriuretic peptides, and increased systemic blood pressure and heart weight to body weight ratios compared to the wild-type mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | isozyme GC-A is a common receptor for atrial and brain natriuretic peptide | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atrium | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | isozyme GC-A is a common receptor for atrial and brain natriuretic peptide | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guanylyl cyclase-A | - |
Mus musculus |