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Literature summary for 4.6.1.2 extracted from

  • Kuhn, M.
    Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases (2009), Handb. Exp. Pharmacol., 191, 47-69.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
isozyme GC-A Homo sapiens
isozyme GC-B Homo sapiens
isozyme GC-C Homo sapiens
isozyme GC-F Homo sapiens
isozymes GC-A to GC-G Mus musculus
isozymes GC-D, GC-E, to GC-G Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-
plasma membrane membrane guanylyl cyclase receptor isozyme GC-A Homo sapiens 5886
-
plasma membrane membrane guanylyl cyclase receptor isozyme GC-B Homo sapiens 5886
-
plasma membrane membrane guanylyl cyclase receptor isozyme GC-C Homo sapiens 5886
-
plasma membrane membrane guanylyl cyclase receptor isozymes GC-D, GC-E, to GC-G Homo sapiens 5886
-
plasma membrane several membrane guanylyl cyclase receptor isozymes, GC-A to GC-G Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus guanylyl cyclase receptors synthesize the second-messenger cyclic GMP 3',5'-cyclic GMP + diphosphate
-
?
GTP Homo sapiens guanylyl cyclase receptors synthesize the second-messenger cyclic GMP 3',5'-cyclic GMP + diphosphate
-
?
additional information Homo sapiens isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart, overview ?
-
?
additional information Mus musculus isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium ?
-
?
additional information Homo sapiens isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification, overview ?
-
?
additional information Homo sapiens isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation, overview ?
-
?
additional information Homo sapiens isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction, overview ?
-
?
additional information Homo sapiens Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozymes GC-D and GC-G appear to be pseudogenes in the human, role of alterations of these ligand/receptor systems in human diseases, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes GC-D, GC-E, and GC-G
-
Homo sapiens P16066 isozyme GC-A; isozyme GC-A
-
Homo sapiens P20594 GC-B; isozyme GC-B
-
Homo sapiens P25092 isozyme GC-C
-
Homo sapiens P51841 isozyme GC-F; isozyme GC-F
-
Mus musculus
-
isozymes GC-A to GC-G
-

Source Tissue

Source Tissue Comment Organism Textmining
artery isozymes GC-A Mus musculus
-
artery isozymes GC-A Homo sapiens
-
endochondral bone isozyme GC-B Mus musculus
-
endochondral bone isozyme GC-B Homo sapiens
-
epithelial cell isozyme GC-C Mus musculus
-
epithelial cell isozyme GC-C Homo sapiens
-
heart isozymes GC-A Mus musculus
-
heart isozymes GC-A Homo sapiens
-
intestine isozyme GC-C Homo sapiens
-
intestine isozymes GC-C and GC-G Mus musculus
-
kidney isozyme GC-G Mus musculus
-
lung isozyme GC-G Mus musculus
-
additional information GC-G has a broad tissue distribution in rodents Mus musculus
-
olfactory neuroepithelium isozyme GC-D is exclusively expressed in the olfactory neuroepithelium in rodents Mus musculus
-
photoreceptor cell isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina Mus musculus
-
photoreceptor cell isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina Homo sapiens
-
retina isozyme GC-E Homo sapiens
-
retina isozyme GC-F Homo sapiens
-
retina isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina Mus musculus
-
retina isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina Homo sapiens
-
skeletal muscle isozyme GC-G Mus musculus
-
sperm isozyme GC-G Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Mus musculus 3',5'-cyclic GMP + diphosphate
-
?
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?
GTP guanylyl cyclase receptors synthesize the second-messenger cyclic GMP Mus musculus 3',5'-cyclic GMP + diphosphate
-
?
GTP guanylyl cyclase receptors synthesize the second-messenger cyclic GMP Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?
additional information isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart, overview Homo sapiens ?
-
?
additional information isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium Mus musculus ?
-
?
additional information isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification, overview Homo sapiens ?
-
?
additional information isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation, overview Homo sapiens ?
-
?
additional information isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction, overview Homo sapiens ?
-
?
additional information Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozymes GC-D and GC-G appear to be pseudogenes in the human, role of alterations of these ligand/receptor systems in human diseases, overview Homo sapiens ?
-
?
additional information structure and functions of membrane guanylate cyclase isozymes, overview Mus musculus ?
-
?

Subunits

Subunits Comment Organism
More isozyme GC-A has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Homo sapiens
More isozyme GC-B has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Homo sapiens
More isozyme GC-C has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Homo sapiens
More isozyme GC-F has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Homo sapiens
More isozymes GC-A to GC-G share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Mus musculus
More isozymes GC-D, GC-E, to GC-G share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview Homo sapiens

Synonyms

Synonyms Comment Organism
membrane guanylyl cyclase receptor
-
Mus musculus
membrane guanylyl cyclase receptor
-
Homo sapiens