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Literature summary for 4.6.1.2 extracted from

  • Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
    Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension (2008), Eur. Respir. J., 32, 881-891.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
BaY 63-2521 i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs Mus musculus
BaY 63-2521 i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs Homo sapiens
BaY 63-2521 i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs Rattus norvegicus
NO physiologic stimulator Mus musculus
NO physiologic stimulator Homo sapiens
NO physiologic stimulator Rattus norvegicus

Application

Application Comment Organism
pharmacology sGC is a target for therapeutic intervention in pulmonary arterial hypertension Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs Mus musculus
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs Homo sapiens
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Mus musculus
-
-
soluble
-
Homo sapiens
-
-
soluble
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview 3',5'-cyclic GMP + diphosphate
-
?
GTP Rattus norvegicus sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a rat lung model, overview 3',5'-cyclic GMP + diphosphate
-
?
GTP Homo sapiens sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in lung explants, overview 3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery pulmonary Mus musculus
-
artery pulmonary Homo sapiens
-
artery pulmonary Rattus norvegicus
-
lung
-
Mus musculus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
smooth muscle pulmonary artery smooth muscle layer Mus musculus
-
smooth muscle pulmonary artery smooth muscle layer Homo sapiens
-
smooth muscle pulmonary artery smooth muscle layer Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Mus musculus 3',5'-cyclic GMP + diphosphate
-
?
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?
GTP
-
Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
?
GTP sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
?
GTP sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a rat lung model, overview Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
?
GTP sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in lung explants, overview Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sGC
-
Mus musculus
sGC
-
Homo sapiens
sGC
-
Rattus norvegicus
soluble guanylate cyclase
-
Mus musculus
soluble guanylate cyclase
-
Homo sapiens
soluble guanylate cyclase
-
Rattus norvegicus