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Literature summary for 4.6.1.2 extracted from

  • Haramis, G.; Zhou, Z.; Pyriochou, A.; Koutsilieris, M.; Roussos, C.; Papapetropoulos, A.
    cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines (2008), Br. J. Pharmacol., 155, 804-813.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
sodium nitroprusside
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
8-bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one i.e. NS-2028, a selective sGC inhibitor, 95% inhibition of enzyme activity at 0.01 mM, inhibits cell proliferation Homo sapiens
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one i.e. QDC, a selective sGC inhibitor, inhibits cell proliferation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens sGC is a receptor for nitric oxide generating cGMP 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell expression of alpha1 and beta1 subunits of sGC Homo sapiens
-
additional information no expression of alpha1 and beta1 subunits of sGC in DU-145 cells Homo sapiens
-
PC-3 cell very low expression of alpha1 and beta1 subunits of sGC Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP sGC is a receptor for nitric oxide generating cGMP Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens