Literature summary for 4.6.1.2 extracted from

Knorr, A.; Hirth-Dietrich, C.; Alonso-Alija, C.; Haerter, M.; Hahn, M.; Keim, Y.; Wunder, F.; Stasch, J.P.
Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis (2008), Arzneimittelforschung, 58, 71-80.

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Activating Compound

Activating Compound	Comment	Organism	Structure
BAY 60-2770	i.e. 4-([(4-carboxybutyl)[2-(5-fluoro-2-([4'-(trifluoromethyl)biphenyl-4-yl]methoxy)phenyl)ethyl]amino]methyl)benzoic acid, NO-independent activation, the compound attenuates pig serum-induced liver fibrosis in vivo but does not affect blodd pressure in spontaneously hypertensive rats, overview	Rattus norvegicus
NO	-	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO cells in a reporter-coupled system, overview	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Rattus norvegicus	-	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	female Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Rattus norvegicus	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sGC	-	Rattus norvegicus
soluble guanylate cyclase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)