Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-(N,N-diethylamino)-diazenolate-2-oxide | stimulates 4.3fold | Rattus norvegicus | |
4-((4-carboxybutyl){2-[(4-phenethyl-benzyl)oxy]-phenethyl}amino)methyl[benzoic]acid | NO- and heme-independent sGC activator, stimulates 15fold, stimulation increases up to 30fold in the presence of 1H-(1,2,4)-oxadiazole-(4,3-a)-quinoxalin-1-one | Rattus norvegicus | |
5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine | NO-independent but heme-dependent sGC stimulator, stimulates the enzyme in a concentration-dependent manner | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | segments spanning amino acids alpha1 363-372, alpha1 403-422, alpha1 440-459, beta1 212-222, beta1 304-333, beta1 344-363, and beta1 381-400 within the predicted dimerization region are involved in the process of heterodimerization and therefore in expression of functional sGC | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
construction of a fluorescent alpha1/beta1-sGC heterodimer by fusion of the N-terminal YFP fragment and the C-terminal fragment to the N terminus and the C terminus of the alpha1- and beta1-subunit, respectively. Generated fusion proteins, wild-type and deletion mutants transiently expressed in a cGMP reporter cell line based on a Chinese hamster ovary cell line stably transfected with the cyclic nucleotide gated olfactory CNG2A-channel and cytosolic aequorin | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | alpha1-sGC and beta1-sGC deletion mutants, coexpression of alpha1-YNV deletion mutants with wild-type-beta1-YCV as well as beta1-YCV deletion mutants with wild-type-beta1-YNV-sGC results in functional heterodimerization of both sGC subunits in the cytosol of the cell | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
heterodimer | deletion mutants, bimolecular fluorescence complementation | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Rattus norvegicus |
soluble guanylate cyclase | - |
Rattus norvegicus |