Literature summary for 4.6.1.2 extracted from

Isenberg, J.S.; Ridnour, L.A.; Thomas, D.D.; Wink, D.A.; Roberts, D.D.; Espey, M.G.
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients (2006), Free Radic. Biol. Med., 40, 1028-1033.

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
diethylamine/NO	increases chemotaxis	Homo sapiens
diethylenetriamine/NO	increases chemotaxis	Homo sapiens

Application

Application	Comment	Organism
medicine	sensitivity of guanylyl cyclase heme nitrosylation as well as oxygen-dependent NO consumption may be particularly adapted to direct itinerant endothelial cells into hypoxic tissues in the setting of inflammation, wound healing, and cancer	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1H-[1,2,4]oxadiazolo[4,3-a]-quinoxalin-1-one	guanylyl cyclase inhibitor, completely abrogates chemotactic and chemokinetic cellular movement to both diethylamine/NO and diethylenetriamine/NO exposure	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
soluble guanylyl cyclase	-	Homo sapiens

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Release 2023.1 (January 2023)