Literature summary for 4.6.1.2 extracted from

Mueller, D.; Cortes-Dericks, L.; Budnik, L.T.; Brunswig-Spickenheier, B.; Pancratius, M.; Speth, R.C.; Mukhopadhyay, A.K.; Middendorff, R.
Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells (2006), Endocrinology, 147, 2974-2985.

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Activating Compound

Activating Compound	Comment	Organism	Structure
atrial natriuretic peptide	highly effective in stimulating cGMP production in MA-10 cells	Mus musculus
atrial natriuretic peptide	increases cGMP production up to 300fold	Rattus norvegicus
brain natriuretic peptide	highly effective in stimulating cGMP production in MA-10 cells	Mus musculus
additional information	C-type natriuretic peptide does not stimulate cGMP production	Mus musculus
additional information	C-type natriuretic peptide does not stimulate cGMP production	Rattus norvegicus

Application

Application	Comment	Organism
additional information	coexistence of homologous and heterologous desensitization of GC-A in the same cell type, these reactions are mediated by different pathways, cross talk between phospholipid and natriuretic peptide signaling	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
atrial natriuretic peptide	elicits GC-A desensitization, can induce decreased GC-A activity in MA-10 Leydig cells, based on mechanisms directly affecting the hormone responsiveness of the receptor. Protein kinase A blocks homologous atrial natriuretic peptide induced desensitization, in which cGMP is generated as second messenger	Mus musculus
lysophosphatidic acid	preincubations for 30 min before assessments of atrial natriuretic peptide-induced cGMP generation reveals inhibitory effects, exerted in a dose-dependent manner, elicits GC-A desensitization, protein kinase A does not block lysophosphatidic acid-induced heterologous desensitization. MEK inhibitor PD 98059 does not protect against the lysophosphatidic acid-mediated decrease in GC-A hormone sensitivity	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Mus musculus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
alphaT3-1 cell	-	Mus musculus	-
brain	-	Rattus norvegicus	-
Leydig cell	-	Rattus norvegicus	-
MA-10 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Mus musculus	3',5'-cyclic GMP + diphosphate	-	?
GTP	-	Rattus norvegicus	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
GC-A	-	Mus musculus
GC-A	-	Rattus norvegicus

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Release 2023.1 (January 2023)