Activating Compound | Comment | Organism | Structure |
---|---|---|---|
atrial natriuretic peptide | - |
Mus musculus | |
atrial natriuretic peptide | - |
Homo sapiens | |
NO | - |
Mus musculus | |
NO | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo | Mus musculus |
medicine | crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | endothelial NO synthase and natriuretic peptide receptor-A knockout mice, sodium nitroprusside and atrial natriuretic peptide produce enhanced dose-dependent reductions in mean arterial blood pressure in endothelial NO synthase knockout mice. In natriuretic peptide receptor-A knockout mice, sodium nitroprusside produces a dose-dependent reduction in mean arterial blood pressure that is significantly higher than that in wild-type mice. Responsiveness to the cAMP-dependent vasodilator epoprostenol is similar in wild-type, endothelial NO synthase and natriuretic peptide receptor-A knockout animals. Atrial natriuretic peptide causes vasodilatation of the forearm resistance vasculature that is significantly higher in individuals lacking endothelium-derived NO | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57/BL6 mice | - |
Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
particulate guanylate cyclase | - |
Mus musculus |
particulate guanylate cyclase | - |
Homo sapiens |
PGC | - |
Mus musculus |
PGC | - |
Homo sapiens |
sGC | - |
Mus musculus |
sGC | - |
Homo sapiens |
soluble guanylate cyclase | - |
Mus musculus |
soluble guanylate cyclase | - |
Homo sapiens |