Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the nitric oxide system is an activator of renal soluble GC | Canis lupus familiaris |
Application | Comment | Organism |
---|---|---|
medicine | different roles of the natriuretic peptide and NO systems. In acute heart failure, the natriuretic peptide system plays a role in maintaining sodium excretion and glomerular filtration rate, while the function of the NO system is in the maintenance of renal blood flow. These two cGMP activating systems function through two distinct GC enzymes, playing a key role in maintaining renal function in acute heart failure | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HS-142-1 | natriuretic peptide released from the heart with acute heart failure target particulate GC, results in a decrease in UNaV and cGMP excretion together with a reduction in glomerular filtration rate and an increase in distal fractional tubular sodium reabsorption | Canis lupus familiaris |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | soluble particle-bound | Canis lupus familiaris | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
mongrel dogs | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Canis lupus familiaris | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
particulate GC | - |
Canis lupus familiaris |
particulate guanylyl cyclase | - |
Canis lupus familiaris |
soluble GC | - |
Canis lupus familiaris |
soluble guanylyl cyclase | - |
Canis lupus familiaris |