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Literature summary for 4.6.1.2 extracted from

  • Martin, F.L.; Supaporn, T.; Chen, H.H.; Sandberg, S.M.; Matsuda, Y.; Jougasaki, M.; Burnett, J.C.
    Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure (2007), Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1580-R1585.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the nitric oxide system is an activator of renal soluble GC Canis lupus familiaris

Application

Application Comment Organism
medicine different roles of the natriuretic peptide and NO systems. In acute heart failure, the natriuretic peptide system plays a role in maintaining sodium excretion and glomerular filtration rate, while the function of the NO system is in the maintenance of renal blood flow. These two cGMP activating systems function through two distinct GC enzymes, playing a key role in maintaining renal function in acute heart failure Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
HS-142-1 natriuretic peptide released from the heart with acute heart failure target particulate GC, results in a decrease in UNaV and cGMP excretion together with a reduction in glomerular filtration rate and an increase in distal fractional tubular sodium reabsorption Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information soluble particle-bound Canis lupus familiaris
-
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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mongrel dogs
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
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Canis lupus familiaris 3',5'-cyclic GMP + diphosphate
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?

Synonyms

Synonyms Comment Organism
particulate GC
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Canis lupus familiaris
particulate guanylyl cyclase
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Canis lupus familiaris
soluble GC
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Canis lupus familiaris
soluble guanylyl cyclase
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Canis lupus familiaris