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Literature summary for 4.6.1.2 extracted from

  • Belik, J.; Hehne, N.; Pan, J.; Behrends, S.
    Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle (2007), Am. J. Physiol. Lung Cell Mol. Physiol., 292, L699-L703.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-2272 sGC stimulant, relaxes newborn, but not adult bronchial muscle Rattus norvegicus
sodium nitroprusside NO donor, significant higher stimulation of sGC activity in newborns compared with adults Rattus norvegicus
YC-1 sGC stimulant, relaxes newborn, but not adult bronchial muscle Rattus norvegicus

Application

Application Comment Organism
additional information bronchial smooth muscle cGMP-, but not cAMP-dependent, relaxant response is developmentally regulated and significantly reduced in the adult rat, correlates with the higher expression of the two isoforms and higher activity of sGC in newborn rat bronchial tissue Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
adult 2-4 months old Rattus norvegicus
-
additional information newborn aged 2–5 days Rattus norvegicus
-
smooth muscle protein expression of the alpha1- and beta1-sGC isoforms is significantly lower in the adult compared with the newborn bronchial tissue Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic AMP + diphosphate
-
 ?
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Rattus norvegicus
soluble guanylate cyclase
-
 Rattus norvegicus