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Literature summary for 4.6.1.2 extracted from

  • Woodard, G.E.; Zhao, J.; Rosado, J.A.
    Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats (2006), Acta Physiol. (Oxf.), 188, 195-206.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
ATP induces a concentration-dependent increase in basal and atrial natriuretic peptide 1-28-stimulated GC activity of glomerular and papillary membranes that is significantly higher in spontaneously hypertensive rats than in age-matched Wistar Kyoto rats Rattus norvegicus
ATPgammaS is more effective than ATP on glomerular and papillary membranes, has little effect on GC activity in solubilized membranes Rattus norvegicus
atrial natriuretic peptide 1-28 increases GC enzymatic activity of glomerular and papillary membranes in a concentration-dependent manner Rattus norvegicus

Application

Application Comment Organism
additional information differences in the effects of ATP on signal transduction of GC-coupled natriuretic peptide receptor A between Wistar Kyoto and spontaneously hypertensive rats Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ATP in solubilized membranes ATP exerts an inhibitory role on basal and atrial natriuretic peptide 1-28-induced GC activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4077
-
 GTP Wistar Kyoto rats, in presence of atrial natriuretic peptide 1-28 and ATP in glomerular membranes Rattus norvegicus
0.5597
-
 GTP Wistar Kyoto rats, in presence of atrial natriuretic peptide 1-28 in glomerular membranes Rattus norvegicus
0.667
-
 GTP Wistar Kyoto rats, in presence of ATP in glomerular membranes Rattus norvegicus
0.8234
-
 GTP Wistar Kyoto rat, basal GC activity of glomerular membranes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane glomerular and papillary membranes Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar Kyoto and spontaneously hypertensive rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?