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Literature summary for 4.6.1.2 extracted from

  • Gille, A.; Lushington, G.H.; Mou, T.C.; Doughty, M.B.; Johnson, R.A.; Seifert, R.
    Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides (2004), J. Biol. Chem., 279, 19955-19969.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2'(3')-O-BODIPY-FL-guanosine 5'-[beta,gamma-imido]triphosphate
-
Bos taurus
2'-deoxy-3'-O-(N-methylanthraniloyl)-ATP
-
Bos taurus
2'-deoxy-3'-O-(N-methylanthraniloyl)-GDP
-
Bos taurus
2'-deoxy-3'-O-(N-methylanthraniloyl)-GTP
-
Bos taurus
2'-deoxy-3'-O-(N-methylanthraniloyl)-guanosine 5'-[beta,gamma-imido]triphosphate
-
Bos taurus
2'-dUTP
-
Bos taurus
BODIPY-FL-GTPgammaS
-
Bos taurus
ITPgammaS
-
Bos taurus
N-methylanthraniloyl-adenosine 5'-[beta,gamma-imido]triphosphate
-
Bos taurus
N-methylanthraniloyl-ADP
-
Bos taurus
N-methylanthraniloyl-ATP
-
Bos taurus
N-methylanthraniloyl-GDP
-
Bos taurus
N-methylanthraniloyl-GTP
-
Bos taurus
N-methylanthraniloyl-GTPgammaS
-
Bos taurus
N-methylanthraniloyl-guanosine 5'-[beta,gamma-imido]triphosphate
-
Bos taurus
N-methylanthraniloyl-ITPgammaS
-
Bos taurus
N-methylanthraniloyl-xanthosine 5'-[beta,gamma-imido]triphosphate
-
Bos taurus
N-methylanthraniloyl-XDP
-
Bos taurus
UTP
-
Bos taurus
UTPgammaS
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Bos taurus
Mn2+ activates Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Bos taurus
-

Storage Stability

Storage Stability Organism
-80°C, 1 year, Vmax decreases by about 50% Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Bos taurus 3',5'-cyclic AMP + diphosphate
-
?
GTP
-
Bos taurus 3',5'-cyclic GMP + diphosphate
-
?
UTP
-
Bos taurus 3',5'-cyclic UMP + diphosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
290
-
GTP pH 7.4, 30°C Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.22
-
2'-deoxy-3'-O-(N-methylanthraniloyl)-GTP pH 7.4, 30°C Bos taurus
0.23
-
N-methylanthraniloyl-adenosine 5'-[beta,gamma-imido]triphosphate pH 7.4, 30°C Bos taurus
0.4
-
N-methylanthraniloyl-ADP pH 7.4, 30°C Bos taurus
0.43
-
N-methylanthraniloyl-ATP pH 7.4, 30°C Bos taurus
0.53
-
2'-deoxy-3'-O-(N-methylanthraniloyl)-guanosine 5'-[beta,gamma-imido]triphosphate pH 7.4, 30°C Bos taurus
0.71
-
N-methylanthraniloyl-GTP pH 7.4, 30°C Bos taurus
1.1
-
N-methylanthraniloyl-GTPgammaS pH 7.4, 30°C Bos taurus
1.3
-
2'(3')-O-BODIPY-FL-guanosine 5'-[beta,gamma-imido]triphosphate pH 7.4, 30°C Bos taurus
1.5
-
N-methylanthraniloyl-guanosine 5'-[beta,gamma-imido]triphosphate pH 7.4, 30°C Bos taurus
1.7
-
N-methylanthraniloyl-xanthosine 5'-[beta,gamma-imido]triphosphate pH 7.4, 30°C Bos taurus
2 5 N-methylanthraniloyl-XDP pH 7.4, 30°C Bos taurus
3.2
-
ITPgammaS pH 7.4, 30°C Bos taurus
3.6
-
2'-deoxy-3'-O-(N-methylanthraniloyl)-ATP pH 7.4, 30°C Bos taurus
4.1
-
UTPgammaS pH 7.4, 30°C Bos taurus
4.2
-
N-methylanthraniloyl-GDP pH 7.4, 30°C Bos taurus
4.9
-
N-methylanthraniloyl-ITPgammaS pH 7.4, 30°C Bos taurus
16
-
UTP pH 7.4, 30°C Bos taurus
16
-
2'-deoxy-3'-O-(N-methylanthraniloyl)-GDP pH 7.4, 30°C Bos taurus
23
-
BODIPY-FL-GTPgammaS pH 7.4, 30°C Bos taurus
24
-
2'-dUTP pH 7.4, 30°C Bos taurus