Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NO | - |
Homo sapiens | |
sodium nitroprusside | NO donor | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of sGCalpha and sGCbeta subunit in Sf1 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H105C | heme-deficient mutant, 70 times higher basal sGC activity than wild-type, basal activity is not affected by NO, heme reconstituted mutant regains No activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | heme moiety of sGC has some inhibitory function on sGC activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant sGC | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
22.1 | - |
NO-stimulated sGC | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | alpha1beta1, heme moiety is localized in beta1 subunit | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |