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Literature summary for 4.6.1.2 extracted from

  • Martin, E.; Sharina, I.; Kots, A.; Murad, F.
    A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation (2003), Proc. Natl. Acad. Sci. USA, 100, 9208-9213.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
NO
-
Homo sapiens
sodium nitroprusside NO donor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of sGCalpha and sGCbeta subunit in Sf1 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H105C heme-deficient mutant, 70 times higher basal sGC activity than wild-type, basal activity is not affected by NO, heme reconstituted mutant regains No activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information heme moiety of sGC has some inhibitory function on sGC activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant sGC Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
22.1
-
NO-stimulated sGC Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Subunits

Subunits Comment Organism
dimer alpha1beta1, heme moiety is localized in beta1 subunit Homo sapiens

Synonyms

Synonyms Comment Organism
sGC
-
Homo sapiens
soluble guanylyl cyclase
-
Homo sapiens