Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTPgammaS | activates by reducing the Km for GTP | Dictyostelium discoideum | |
GTPgammaS | activates by reducing the Km for GTP, half-maximal activation at 0.008 mM | Dictyostelium sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 0.00005 mM, 50% inhibition | Dictyostelium discoideum | |
Ca2+ | 0.0002 mM, 50% inhibition | Dictyostelium sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
GTP | 22°C, pH 8.0 | Dictyostelium discoideum | |
0.41 | - |
GTP | 22°C, pH 8.0 | Dictyostelium sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Dictyostelium discoideum | 16020 | - |
soluble | - |
Dictyostelium sp. | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | maximal activity at 1-2 mM, 5fold lower activity than with Mn2+ | Dictyostelium sp. | |
Mg2+ | predominantly active with Mg2+/GTP | Dictyostelium discoideum | |
Mn2+ | maximal activity at 1-2 mM | Dictyostelium sp. | |
Mn2+ | supports only 30% of Mg2+-dependent activity | Dictyostelium discoideum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Dictyostelium discoideum | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Dictyostelium sp. | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
during growth, 20-40% of GC activity is attributed to GCA | - |
Dictyostelium sp. | - |
during growth, 60-80% of GC activity is attributed to sGC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Dictyostelium discoideum | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Dictyostelium sp. | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCA | - |
Dictyostelium discoideum |
guanylyl cyclase A | - |
Dictyostelium discoideum |
sGC | - |
Dictyostelium sp. |
soluble guanylyl cyclase | - |
Dictyostelium sp. |