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Literature summary for 4.6.1.2 extracted from

  • Serfass, L.; Carr, H.S.; Aschenbrenner, L.M.; Burstyn, J.N.
    Calcium ion downregulates soluble guanylyl cyclase activity: Evidence for a two-metal ion catalytic mechanism (2001), Arch. Biochem. Biophys., 387, 47-56.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
NO
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ inhibition of both, the basal and NO-stimulated forms of sGC, competitive vs. Mg2+, noncompetitive vs. MgGTP Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ one Mg2+ is primarily associated with the enzyme and the second is directly bound to the alpha, beta and gamma phosphates of GTP Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Bos taurus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Bos taurus
soluble guanylyl cyclase
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.029
-
 Ca2+ 37°C, pH 7.4, competitive vs. Mg2+ Bos taurus
0.096
-
 Ca2+ 37°C, pH 7.4, noncompetitive vs. MgGTP Bos taurus