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Literature summary for 4.6.1.19 extracted from

  • Ke, X.D.; Shen, S.; Song, L.J.; Yu, C.X.; Kikuchi, M.; Hirayama, K.; Gao, H.; Wang, J.; Yin, X.; Yao, Y.; Liu, Q.; Zhou, W.
    Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function (2017), Parasit. Vectors, 10, 89 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
diethyldicarbonate
-
 Schistosoma japonicum

Organism

Organism UniProt Comment Textmining
Schistosoma japonicum Q6PYW1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg the CP1412 protein is exclusively secreted/excreted from eggs, but not cercariae and adult worms Schistosoma japonicum
-

Synonyms

Synonyms Comment Organism
CP1412
-
 Schistosoma japonicum

General Information

General Information Comment Organism
malfunction depletion of CP1412 from soluble egg antigen impairs the ability of soluble egg antigen to induce M2 type polarization of RAW264.7macrophages. Immunizing mice with CP1412 induces high antibody titers, increased serum IL-4 and TGF-beta levels and splenic CD4 + CD25 + Foxp3 + T cells, downregulated serum IFN-gamma levels and alleviated the egg granuloma pathology of schistosome infection. In vitro stimulation by rSj CP1412 significantly increased CD4 + CD25 + Foxp3 + T cell numbers in splenocytes of healthy mice. The CP1412 protein with RNase activity inactivated by diethyldicarbonate fails to induce M2 surface marker CD206 expression in RAW264.7 macrophages Schistosoma japonicum
metabolism stimulating RAW264.7 macrophages with recombinant CP1412 raises the expression of CD206, Arg-1 and IL-10, which are related to M2 type macrophage differentiation. Stimulating dendritic cells with rSjCP1412 fails to induce their maturation, and the recombinant protein also inhibits LPS-stimulated dendritic cell maturation Schistosoma japonicum