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Literature summary for 4.6.1.19 extracted from

  • Huang, J.; Liu, P.; Wang, G.
    Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2) (2018), J. Biol. Chem., 293, 19633-19644 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial intermembrane space
-
Mus musculus 5758
-
mitochondrial intermembrane space
-
Homo sapiens 5758
-
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens C0HKG5
-
-
Mus musculus C0HKG5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
RNase T2
-
Mus musculus
RNase T2
-
Homo sapiens
RNaseT2
-
Mus musculus
RNaseT2
-
Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of the protein in an immortalized mouse cell line TM6 decreases the degradation rate Mus musculus
metabolism the enzyme degrades mitochondrial RNAs and it is also responsible for selective degradation of the cytosolic rRNAs on the outer membrane. The degradation activity also has a positive effect on nuclear transcription of rRNAs, suggesting a compensatory feedback mechanism, and affects protein translations in and out of mitochondria Mus musculus
metabolism the enzyme degrades mitochondrial RNAs and it is also responsible for selective degradation of the cytosolic rRNAs on the outer membrane. The degradation activity also has a positive effect on nuclear transcription of rRNAs, suggesting a compensatory feedback mechanism, and affects protein translations in and out of mitochondria Homo sapiens