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Literature summary for 4.6.1.19 extracted from
- New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1alpha (2018), Hum. Pathol., 79, 66-76 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00584 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | neuroendocrine neoplasms of the lung, well differentiated and poorly differentiated | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RNaseT2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | overexpression of RNASET2 in consequence of the activation of HIF-1alpha. | up |
| Homo sapiens | significantly higher expression of RNASET2, HIF-1alpha, and its target CA IX in poorly differentiated than in well-differentiated LuNENs | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | there is a possible link between the hypoxic state experienced by cancer cells and the expression level of RNASET2. A role of this gene as a stress-response factor is postulated | Homo sapiens |
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