Literature summary for 4.6.1.19 extracted from

Jacobs, A.C.; Blanchard, C.E.; Catherman, S.C.; Dunman, P.M.; Murata, Y.
An ribonuclease T2 family protein modulates Acinetobacter baumannii abiotic surface colonization (2014), PLoS ONE, 9, e85729.

Search for more literature for 4.6.1.19

Application

Application	Comment	Organism
additional information	the enzyme may be an effective target for the intervention of biomaterial colonization, and consequently limit the organisms transmission within the hospital setting	Acinetobacter baumannii

Protein Variants

Protein Variants	Comment	Organism
additional information	transposon mutagenesis analysis of abiotic surface-colonization of wild-type and enzyme-deletion mutant strain 98-37-09, the mutant exhibits reduced expression of 29 genes, 15 of which are predicted to be associated with bacterial attachment and surface-associated motility, overview	Acinetobacter baumannii

Organism

Organism	UniProt	Comment	Textmining
Acinetobacter baumannii	-	-	-
Acinetobacter baumannii 98-37-09	-	-	-

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the ribonuclease T2 family	Acinetobacter baumannii
malfunction	disruption of the RNase T2 family gene limits the organism's ability to colonize polystyrene, polypropylene, glass, and stainless steel surfaces, transposon mutagenesis analysis of abiotic surface-colonization of wild-type and mutant strain 98-37-09, the mutant exhibits reduced expression of 29 genes, 15 of which are predicted to be associated with bacterial attachment and surface-associated motility, overview	Acinetobacter baumannii
physiological function	the enzyme is a positive regulator of Acinetobacter baumannii's ability to colonize inanimate surfaces and motility	Acinetobacter baumannii

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Release 2023.1 (January 2023)