Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2',5'-Oligoadenylate | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged wild-type, R667A mutant, and NDELTA385 deletion enzyme mutant in HeLa-M cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion mutant NDELTA385 is a constitutively active form of RNase L | Homo sapiens |
R667A | a catalytically inactive RNase L mutant | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | e.g. ATCC CCL-2 and S3, express normal enzyme level, while strain HeLa-M is defective in RNase L expression | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
RNase L | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA-mediated depletion of endogenous enzyme in the human ovarian cancer cell line Hey1b increased the levels of LINE-1 retrotransposition by about 2fold. Recombinant expression of wild-type and a constitutively active deletion mutant enzyme form, but not a catalytically inactive enzyme mutant R667A, impair the mobility of engineered human LINE-1 and mouse intracisternal A-type particle retrotransposons in cultured human cells | Homo sapiens |
physiological function | the enzyme might function as a suppressor of structurally distinct retrotransposons, endogenous RNase L restricts L1 retrotransposition, overview. Wild-type enzyme, but not enzyme mutant R667A, prevents formation of LINE-1 cytoplasmic foci | Homo sapiens |