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Literature summary for 4.6.1.19 extracted from

  • Polakowski, N.; Han, H.; Lemasson, I.
    Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax (2011), Viruses, 3, 1485-1500.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.19

Cloned(Commentary)

Cloned (Comment) Organism
gene RNASET2, real-time PCR expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus RNase T2 is located within a region of the long arm of chromosome six that undergoes deletion or rearrangement in many cancers, including some cases of adult T-cell leukemia, ATL Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 gene RNASET2
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Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
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lymphocyte
-
 Homo sapiens
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Synonyms

Synonyms Comment Organism
RNase T2
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens reduction in the level of RNase T2 by Tax protein from human T cell leukemia virus type 1 down

General Information

General Information Comment Organism
additional information a reduction in the level of RNase T2 by Tax may play a role in adult T-cell leukemia, ATL, development, one of the primary diseases caused by human T cell leukemia virus type 1, HTLV-1, infection, ability of the viral protein to directly deregulate expression of specific cellular genes through interactions with numerous transcriptional regulators, e.g. the virally-encoded Tax protein, overview. Tax is renriched at the RNASET2 gene Homo sapiens
physiological function ribonuclease T2 is known to play a role in senescence in plants and possibly mammalian cells and may be an important tumor suppressor Homo sapiens