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Literature summary for 4.6.1.19 extracted from
- Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function (2007), PLoS ONE, 3, e317.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| P509L | mutant contains a reduced RNase activity, the spindle-kinetochore interaction is abnormal in mutant cells, associated with mitotic arrest at a pre-anaphase stage | Schizosaccharomyces pombe |
| T808A | mutant contains a reduced RNase activity | Schizosaccharomyces pombe |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA + H2O | Schizosaccharomyces pombe | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA + H2O | - |
Schizosaccharomyces pombe | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dis3 ribonuclease | member of the RNase II family | Schizosaccharomyces pombe |
| ribonuclease | - |
Schizosaccharomyces pombe |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
RNase assay | Schizosaccharomyces pombe |
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Release 2023.1 (January 2023)
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