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Literature summary for 4.6.1.18 extracted from

  • Samanta, A.; Dasgupta, S.; Pathak, T.
    5'-modified pyrimidine nucleosides as inhibitors of ribonuclease A (2011), Bioorg. Med. Chem., 19, 2478-2484.
    View publication on PubMed
Search for more literature for 4.6.1.18

Inhibitors

Inhibitors Comment Organism Structure
1-(2,5-dideoxy-5-(4-carboxypiperidinyl)-beta-D-threo-pentofuranosyl)thymine
-
 Bos taurus
5'-deoxy-5'-N-(4-carboxypiperidinyl)thymidine
-
 Bos taurus
5'-deoxy-5'-N-(4-carboxypiperidinyl)uridine
-
 Bos taurus
5'-N-(4-carboxypiperidinyl)-2',3'-didehydro-3',5'-dideoxythymidine
-
 Bos taurus
additional information inhibitor synthesis, kinetics, and docking, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P61823
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-cCMP + H2O
-
 Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
ribonuclease A
-
 Bos taurus
RNase A
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.075
-
 5'-deoxy-5'-N-(4-carboxypiperidinyl)uridine pH 7.5, 25°C Bos taurus
0.162
-
 5'-deoxy-5'-N-(4-carboxypiperidinyl)thymidine pH 7.5, 25°C Bos taurus
0.229
-
 1-(2,5-dideoxy-5-(4-carboxypiperidinyl)-beta-D-threo-pentofuranosyl)thymine pH 7.5, 25°C Bos taurus
0.25
-
 5'-N-(4-carboxypiperidinyl)-2',3'-didehydro-3',5'-dideoxythymidine pH 7.5, 25°C Bos taurus