Literature summary for 4.6.1.18 extracted from

Tsirkone, V.G.; Dossi, K.; Drakou, C.; Zographos, S.E.; Kontou, M.; Leonidas, D.D.
Inhibitor design for ribonuclease A: the binding of two 5-phosphate uridine analogues (2009), Acta Crystallogr. Sect. F, 65, 671-677.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
vapor-diffusion, hanging-drop, PEG 4000, sodium citrate, pH 5.5, temperature 289 K, ribonuclease A-uridine 5 phosphate complex, resolution 1.39 A, space group C121, ribonuclease A-uridine 5 diphosphate complex, resolution 1.40 A, space group C121	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
uridine 5'-diphosphate	competitive inhibitor	Bos taurus
uridine 5'-phosphate	competitive inhibitor	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P61823	-	-

Synonyms

Synonyms	Comment	Organism
pancreatic ribonuclease A	-	Bos taurus
RNase A	-	Bos taurus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.65	-	uridine 5'-diphosphate	binds to the active site of the enzyme by anchoring two molecules connected to each other by hydrogen bonds and van der Waals interactions	Bos taurus
4	-	uridine 5'-phosphate	binds to the active site of the enzyme by anchoring two molecules connected to each other by hydrogen bonds and van der Waals interactions	Bos taurus

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Release 2023.1 (January 2023)