Literature summary for 4.6.1.18 extracted from

Barrabes, S.; Pages-Pons, L.; Radcliffe, C.M.; Tabares, G.; Fort, E.; Royle, L.; Harvey, D.J.; Moenner, M.; Dwek, R.A.; Rudd, P.M.; De Llorens, R.; Peracaula, R.
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer (2007), Glycobiology, 17, 388-400.

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Application

Application	Comment	Organism
medicine	RNase 1 from human healthy pancreas contains only neutral glycans, whereas RNase 1 from pancreas cancer cell lines contains sialylated structures. In serum from patients with pancreatic cancer, there is an increase of 40% in core fucosylation in the main sialylated biantennary glycans of RNase 1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	RNase 1 from human healthy pancreas contains only neutral glycans, whereas RNase 1 from pancreas cancer cell lines contains sialylated structures. In serum from patients with pancreatic cancer, there is an increase of 40% in core fucosylation in the main sialylated biantennary glycans of RNase 1	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	endothelial cells are the main source of serum enzyme	Homo sapiens	-
pancreas	pancreas cancer cell	Homo sapiens	-
serum	main source of serum enzyme are endothelial cells	Homo sapiens	-

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Release 2023.1 (January 2023)