Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.18 extracted from

  • Johnson, R.J.; Lin, S.R.; Raines, R.T.
    A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus (2006), FEBS J., 273, 5457-5465.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
H2O2
-
Bos taurus
H2O2
-
Homo sapiens
ribonuclease inhibitor extremely tight complex with bovine ribonuclease inhibitor, Kd value 0.69 fM. Kd value of complex with human ribonuclease inhibitor 0.34 fM Bos taurus
ribonuclease inhibitor tight complex with human ribonuclease inhibitor, Kd value 0.34 fM. Kd value of complex with bovine ribonuclease inhibitor 35 fM Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
66.6
-
melting temperature of complex with human ribonuclease inhibitor Homo sapiens
68
-
melting temperature of complex with bovine ribonuclease inhibitor Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
64.2
-
melting temperature of complex with human ribonuclease inhibitor Bos taurus
68.6
-
melting temperature of complex with bovine ribonuclease inhibitor Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.028
-
oxidative stability of complex with human ribonuclease inhibitor Homo sapiens H2O2
0.029
-
oxidative stability of complex with bovine ribonuclease inhibitor Homo sapiens H2O2
0.042
-
oxidative stability of complex with human ribonuclease inhibitor Bos taurus H2O2
0.3
-
oxidative stability of complex with bovine ribonuclease inhibitor Bos taurus H2O2