Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NaCl | - |
Homo sapiens | |
NaCl | - |
Bos taurus | |
NaCl | - |
Lithobates pipiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
onconase/RNase A hybrid protein, expression in Escherichia coli | Lithobates pipiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NaCl | - |
Bos taurus | |
NaCl | - |
Homo sapiens | |
NaCl | - |
Lithobates pipiens | |
Polyanions | natural and synthetic, free poly(A), poly(U) | Bos taurus | |
ribonuclease inhibitor | - |
Bos taurus | |
ribonuclease inhibitor | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RNA + H2O | Homo sapiens | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Bos taurus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Lithobates pipiens | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Lithobates pipiens | - |
frog, mutant | - |
Purification (Comment) | Organism |
---|---|
of the recombinant and mutant protein | Lithobates pipiens |
of the recombinant protein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
egg | - |
Lithobates pipiens | - |
pancreas | - |
Homo sapiens | - |
pancreas | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CpA + H2O | - |
Bos taurus | adenosine + 3'-CMP | - |
? | |
CpA + H2O | - |
Lithobates pipiens | adenosine + 3'-CMP | - |
? | |
poly (C) + H2O | - |
Homo sapiens | 3'-CMP + 3'-phosphooligonucleotides | - |
? | |
poly (C) + H2O | - |
Bos taurus | 3'-CMP + 3'-phosphooligonucleotides | - |
? | |
poly (C) + H2O | - |
Lithobates pipiens | 3'-CMP + 3'-phosphooligonucleotides | - |
? | |
poly U + H2O | - |
Homo sapiens | 3'-UMP + 3'-oligonucleotides | - |
? | |
poly U + H2O | - |
Lithobates pipiens | 3'-UMP + 3'-oligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Bos taurus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Lithobates pipiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
tRNA + H2O | onconase, similar enzyme | Lithobates pipiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
UpG + H2O | - |
Bos taurus | guanosine + 3'-UMP | - |
? | |
UpG + H2O | - |
Lithobates pipiens | guanosine + 3'-UMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
onconase | - |
Lithobates pipiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Lithobates pipiens |