Literature summary for 4.6.1.18 extracted from

Russo, N.; de Nigris, M.; Ciardiello, A.; Di Donato, A.; D'Alessio, G.
Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease (1993), FEBS Lett., 333, 233-237.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNA + H2O	Homo sapiens	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclic 2',3'-nucleoside monophosphate + H2O	second step of hydrolysis is irreversible	Homo sapiens	3'-phosphomononucleotides	-	ir
double-stranded poly(A)-poly(U) + H2O	-	Homo sapiens	3'-UMP + 3'-oligonucleotides	-	?
RNA + H2O	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	Homo sapiens	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?
RNA + H2O	first step of hydrolysis is reversible	Homo sapiens	cyclic 2',3'-nucleoside monophosphate	-	r

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Release 2023.1 (January 2023)