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Literature summary for 4.6.1.18 extracted from
- Human milk ribonuclease (1980), Biochim. Biophys. Acta, 615, 381-391.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| KCl | - |
Homo sapiens |  |
| NaCl | - |
Homo sapiens | |
| Sodium citrate | - |
Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | - |
Homo sapiens | |
| CuSO4 | - |
Homo sapiens | |
| FeSO4 | - |
Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
| ZnSO4 | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | increases activity | Homo sapiens | |
| Na+ | increases activity | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14020 | - |
milk, sedimentation ultracentrifugation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA + H2O | Homo sapiens | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| milk | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Homo sapiens | 3'-phosphomononucleotides | - |
ir | |
| poly (C) + H2O | - |
Homo sapiens | 3'-CMP + 3'-phosphooligonucleotides | - |
? | |
| poly U + H2O | - |
Homo sapiens | 3'-UMP + 3'-oligonucleotides | - |
? | |
| RNA + H2O | not: single-stranded homopolyribonucleotides other than poly(C) and poly(U) | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
| RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
| RNA + H2O | first step of hydrolysis is reversible | Homo sapiens | cyclic 2',3'-nucleoside monophosphate | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
- |
Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 70 | 25°C: about 5% of activity maximum, 70°C: about 45% of activity maximum | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 3 | 9 | pH 3.0: about 10% of activity maximum, pH 9.0: about 5% of activity maximum | Homo sapiens |
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Release 2023.1 (January 2023)
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