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Literature summary for 4.6.1.18 extracted from

  • Bartholeyns, J.; Baudhuin, P.
    Purification of rat liver particulate neutral ribonuclease and comparison of properties with pancreas and serum ribonucleases (1977), Biochem. J., 163, 675-683.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.18

General Stability

General Stability Organism
24 h, 125 mM H2SO4, no loss of activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
liver natural inhibitor
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA + H2O Rattus norvegicus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
serum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Rattus norvegicus 3'-phosphomononucleotides
-
 ir
RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Rattus norvegicus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O specific for pyrimidine bases Rattus norvegicus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O first step of hydrolysis is reversible Rattus norvegicus cyclic 2',3'-nucleoside monophosphate
-
 r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
 no loss of activity after 50 min, pH 5 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
-
 Rattus norvegicus
8
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 10 pH 6: about 15% of activity maximum, pH 10: about 10% of activity maximum Rattus norvegicus